Two bowel cistrons of cancer discovered
Two bowel cistrons of cancer discovered
British researchers believe they have explained why some families are incredibly vulnerable to cancer. They have two genes that are transferred from mother to child, which greatly chances of a tumor. The study, published in Nature Genetics, analyzed DNA from 20 individuals with a strong family history.
The results can be used to provide a test person's risk of developing the disease, to be assessed. One of the people who participated in the study, Joe Wiegand from Hampshire, diagnosed with cancer when he was 28 Most of his colon had to be removed.
"There is a very strong history of cancer in my family - my father, mother and sister both had, my father was diagnosed with it at 43 and a few cousins have had colon cancer and brain tumors.
"It is clear that something is going on in our family."
The researchers looked at the genetic code of 20 people and found errors in two genes may increase the risk of developing cancer to grow.
Prevention
Lead researcher Professor Ian Tomlinson at the University of Oxford, said: "There are some families where a large number of families to develop colorectal cancer, but has none of the known gene defects that increase the risk of developing the disease increases.
"These two errors are rare, but if you inherit them the risk of colorectal cancer is high."
He said that in the short-term results can be used to determine which people are at increased risk of developing colon cancer, and had in families with a high incidence of cancer, in order to determine what people in danger, and had to more frequent screening.
He said it was "possible" that specific therapies can be designed to overcome these mutations in the future.
Professor Richard Houlston from The Institute of Cancer Research, said the findings were "one of the most important discoveries in cancer genetics in years."
Dr Julie Sharp, of Cancer Research UK, said the study was "another piece of the puzzle" for vulnerable families.
She said the results mean, "doctors can help families with a strong family history of cancer prevention to develop or diagnose it earlier to help more people survive."
British researchers believe they have explained why some families are incredibly vulnerable to cancer. They have two genes that are transferred from mother to child, which greatly chances of a tumor. The study, published in Nature Genetics, analyzed DNA from 20 individuals with a strong family history.
The results can be used to provide a test person's risk of developing the disease, to be assessed. One of the people who participated in the study, Joe Wiegand from Hampshire, diagnosed with cancer when he was 28 Most of his colon had to be removed.
"There is a very strong history of cancer in my family - my father, mother and sister both had, my father was diagnosed with it at 43 and a few cousins have had colon cancer and brain tumors.
"It is clear that something is going on in our family."
The researchers looked at the genetic code of 20 people and found errors in two genes may increase the risk of developing cancer to grow.
Prevention
Lead researcher Professor Ian Tomlinson at the University of Oxford, said: "There are some families where a large number of families to develop colorectal cancer, but has none of the known gene defects that increase the risk of developing the disease increases.
"These two errors are rare, but if you inherit them the risk of colorectal cancer is high."
He said that in the short-term results can be used to determine which people are at increased risk of developing colon cancer, and had in families with a high incidence of cancer, in order to determine what people in danger, and had to more frequent screening.
He said it was "possible" that specific therapies can be designed to overcome these mutations in the future.
Professor Richard Houlston from The Institute of Cancer Research, said the findings were "one of the most important discoveries in cancer genetics in years."
Dr Julie Sharp, of Cancer Research UK, said the study was "another piece of the puzzle" for vulnerable families.
She said the results mean, "doctors can help families with a strong family history of cancer prevention to develop or diagnose it earlier to help more people survive."
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